JIN_FK8R Please rate my stack I know I'm Fxxked up for now. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Cathy Wong is a nutritionist and wellness expert. Milk thistle may not be safe for everyone. Questions? In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. This is especially important if you are taking any other medications for menopause or any blood thinners, such as statins. Its anti-inflammatory and antioxidant properties mean that it is possibly neuroprotective and could help prevent the decline in brain function you experience as you age (14, 15). . Closer to a Cancer Cure? However, there are currently no human studies, so its effectiveness remains unclear. 8600 Rockville Pike In fact, a recent review and analysis found that people routinely taking silymarin experienced a significant reduction in their fasting blood sugar levels and HbA1c, a measure of blood sugar control (44). 1. https://iocdf.org/about-ocd/ocd-treatment/meds/, International OCD Foundation, Medications for OCD, By By Michael Jenike, MD, Retrieved May 5, 2019, 2. https://theoakstreatment.com/blog/ocd-facts-and-statistics/, The Oaks Treatment, OCD Facts and Statistics, Published June 18, 2018, Retrieved May 5, 2019, 3. https://www.psycom.net/ocd-medication-guide/, Psycom.net, OCD Medication Guide, By Kathleen Smith, PhD, Last Updated September 21, 2018, 4. https://www.ncbi.nlm.nih.gov/pubmed/20564545, Phtotherapy Research, Milk thistle in liver diseases: past, present, future, Published October 24, 2010, Retrieved May 5, 2019, 5. https://www.drugs.com/npp/milk-thistle.html, Drugs.com, Milk Thistle, Last updated on Mar 1, 2019, Retrieved May 5, 2019, 6. https://www.verywellhealth.com/the-benefits-of-milk-thistle-88325, VeryWellHealth.com, The Benefits of Milk Thistle, By Kathee Wong, Updated March 08, 2019, Retrieved May 5, 2019, 7. https://linkinghub.elsevier.com/retrieve/pii/S0944711315000227, Phytomedicine, Effects of Silybum marianum (L.) Gaertn. Milk thistle may not be recommended in some situations. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Satisfaction. National Center for Complementary and Integrative Health. Milk thistle (PDQ): Health Professional Version. These side effects may be mild or severe. 5th ed. doi:10.1097/CAD.0000000000000211, Fallah M, Davoodvandi A, Nikmanzar S, et al. This content does not have an English version. Do not use this product without medical advice if you are breast-feeding a baby. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. The silymarin extracted from milk thistle is known to have antioxidant, antiviral and anti-inflammatory properties (2, 3, 4). It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Can Milk Thistle Help People With Diabetes? However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). 10 Supplements You Should Be Taking After Menopause We comply with the HONcode standard for trustworthy health information. Just amazing and timely information at your fingertips. One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Before In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). https://www.micromedexsolutions.com. Silymarin as supportive treatment in liver diseases: a narrative review. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. There is also concern that milk thistle might affect estrogen levels. Quality and active ingredients in supplements may vary widely from maker to maker. 2008;47(2):605-12. doi:10.1002/hep.22044, Fried MW, Navarro VJ, Afdhal N, et al. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Using different formulations together increases the risk of an overdose. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. 2014;2014:941085. doi:10.1155/2014/941085. Its been discovered that one of the compounds in milk thistle may work similarly to some diabetic medications by helping improve insulin sensitivity and decrease blood sugar (43). Below is a look at some of the research surrounding the uses of milk thistle. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. Minerals for OCD Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. Accessed Oct. 30, 2020. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Multiple Myeloma vs. Leukemia: What Are the Differences? Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. 2005 - 2023 WebMD LLC, an Internet Brands company. 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971. The therapeutic potential of milk thistle in diabetes. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). Historically, people have used milk thistle for liver disorders and gallbladder problems. Read our. and depression. Depression. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Silibinin attenuates allergic airway inflammation in mice Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. However, its currently unclear if it has the same beneficial effects in humans. Did you know that milk thistle has recently been touted as a natural remedy to help manage the debilitating symptoms of OCD? And although milk thistle extract is commonly used as a complementary therapy for people with liver diseases, theres currently no evidence that it can prevent you from getting these conditions, especially if you have an unhealthy lifestyle. 2007;2007(4):CD003620. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Bethesda, MD 20894, Web Policies There are other supplements that work similarly to milk thistle. More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). Consult with a licensed healthcare professional before using any herbal/health supplement. Efficacy and safety of milk thistle preventive treatment of anti - LWW Before taking milk thistle, talk to your doctor, pharmacist, or health care professional if you have allergies (especially to plants), have any medical conditions, or if you take other medicines or other herbal/health supplements. Verywell Health's content is for informational and educational purposes only. The https:// ensures that you are connecting to the Accessed Oct. 30, 2020. Milk Thistle is used to treat alcoholic liver disease, gallbladder problems, hepatic cirrhosis, hepatitis (chronic), hepatotoxicity (chemical/drug-induced), jaundice, pleurisy, prostate cancer, and spleen diseases, and used as an appetite stimulant.. Find out more on the side effects of statins. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time. J Tradit Complement Med. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). Milk Thistle: Generic, Uses, Side Effects, Dosages - RxList Do not take milk thistle without medical advice if you are using a medication to treat any of the following conditions: any type of infection (including HIV, malaria, or tuberculosis); arthritis pain, occasional pain, or tension headaches (including Advil, Motrin, or Celebrex); heartburn or gastroesophageal reflux disease (GERD); high blood pressure, high cholesterol, or a heart condition; psoriasis, rheumatoid arthritis, or other autoimmune disorders; This list is not complete. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Depression and anxiety are associated with increased risk of developing AD. . Review/update the Thank you, {{form.email}}, for signing up. 3 Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. If you take any medicines regularly, talk to your doctor before you start using milk thistle. However, the evidence is conflicting. About curcumin, it isn't usually a problem but if you're on IMAOs you may like to read a bit before taking high doses. New Treatments That May Change the Game, The Latest Research on Advanced Prostate Cancer. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver diseases. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. Milk thistle's main active component is silymarin which works by normalizing levels of both serotonin and dopamine. 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Natural Medicines website. In: Textbook of Natural Medicine. People mainly use the supplement to treat liver conditions. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. Get the facts on milk thistle for the liver. https://naturalmedicines.therapeuticresearch.com. I think milk thistle is often used in combo with NAC to enhance it's beneficial effects. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Can You Get Milk Thistle Naturally From Foods? Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. However, many of these potential benefits are not backed by science. Large-scale, properly-designed studies are needed. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Silibinin significantly attenuated anxiety/depression-like behaviors caused by A1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). What Is Complementary, Alternative, or Integrative Health? Bookshelf Risks. eCollection 2022. In: Drugs and Lactation Database (LactMed). Milk thistlesupplementscontaining silymarin are commonly sold as teas or in capsule form, but are also available as tablets, soft gels, and liquid extracts. 2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. This herb (also known as Silybum marianum) is native to the Mediterranean region. MILK THISTLE - Uses, Side Effects, and More - WebMD Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Fried, M.; Navarro, V.; Afdhal, N. et al. Effect of silymarin on chemical, functional, and morphological alterations of the liver. National Center for Complementary and Integrative Health. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Copyright 2017 Elsevier Inc. All rights reserved. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. Cochrane Database Syst Rev. However, there is no solid evidence that supports these claims. Milk thistle contains compounds that may support skin, liver, and bone health and enhance weight loss. What Are the Risks of Taking Milk Thistle? [Database subscription]. Learn. Milk Thistle Benefits - Verywell Health Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. A double-blind controlled study. An official website of the United States government. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. How Long Does It Take for Milk Thistle to Work? - LiverSupport.com There is a problem with Anxiety; Autophagy; BDNF; Depression; Silibinin. National Library of Medicine However, there is a lack of . Scan J Gastroenterol. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. There are no other food sources of this herb. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. 2023 Healthline Media LLC. Adv Ther. A 2010 review by researchers found that black . Comparing Natural Remedies for OCD to Standard OCD Treatment Unauthorized use of these marks is strictly prohibited. However, there is no solid evidence that supports these claims. Healthline Media does not provide medical advice, diagnosis, or treatment. This article will explore the uses of milk thistle and research on its potential benefits. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Camini FC, Costa DC. Some people may be allergic to milk thistle. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. other information we have about you. 7 likes, 2 comments - lyndsey | nutrition + fertility + herbalism + birth (@rooted_in_ritual) on Instagram: " Ways to Prepare for Ovulation Ovulation is the . Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. People with diabetes should use caution. Silymarin is an active component of milk thistle, which is not found in foods. Antidepressant and Anti-anxiety Effects of Milk Thistle However, few of these claims are supported by solid evidence. Some people are advised to be cautious when taking milk thistle. The site is secure. 2023 May;475(5):621-635. doi: 10.1007/s00424-023-02795-y. Research shows that the silymarin in milk thistle helps protect the liver from many industrial toxins, such as carbon tetrachloride. Phytother Res. Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. Neurological Disorders Milk thistle has long been used to alleviate the inflammation commonly associated with a host of neurological disorders such as dementia, Alzheimers, and Parkinsons Disease (8). If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. Milk Thistle Health Benefits: Antioxidant and Anti-inflammatory National Library of Medicine (US); 2022. Herbal Remedies for OCD and Anxiety Disorders - Verywell Mind Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. Huberman: "Anything that reduces 5-alpha reductase is going to reduce DHT & maintain or extend the growth phase, the anagen phase, of hair growth. Milk thistle is a popular herbal remedy best known for its liver-protecting properties. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Federal government websites often end in .gov or .mil. information and will only use or disclose that information as set forth in our notice of Silybum marianum (milk thistle). Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. doi:10.1515/jbcpp-2019-0206, Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Milk thistle is generally considered safe when taken by mouth (1, 45). Other studies looking at milk thistle for cirrhosis have found conflicting results. But the herb is also believed to be beneficial for other health issues. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. While the cost of most OCD medications currently available on the market is actually quite reasonable, the common side effects that occur are definitely not. National Cancer Institute PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. In reducing oxidative stress, milk thistle is believed to be neuroprotective by helping prevent decline in brain function. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. the unsubscribe link in the e-mail. Hepatology. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Milk thistle. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Its herbal remedy is known as milk thistle extract. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. health information, we will treat all of that information as protected health Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Eighteen clinical trials of 1,088 participants were assessed. Medically reviewed by Drugs.com on Sep 29, 2022. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. The best doses of milk thistle have not been established for any condition it may be used to treat. Natural Medicines. By using our site, you acknowledge that you have read and understand our. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver).